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pentobarbital will reduce the level or outcome of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with solid CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.Although it may be used being a sedative and anticonvulsant by physicians,